South Dakota Gov. Kristi Noem (R) invited comedian and HBO host Bill Maher to visit her state to see what Middle America is all about. 

In Maher's closing monologue Friday night, he centered on Amazon's decision not to build a new headquarters in New York City. He said the richest company in the world can "do good" by bringing the project to a so-called "fly-over state."

"We have a problem in America called spatial geographic inequality which means the most affluent and educated people are clustered in just a few cities," he said, going on to deride Middle America as less educated and less affluent.

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"We have orchestras and theaters districts and world-class shopping. We have Chef Wolfgang Puck, they have Chef Boyardee," he joked. 

Noem responded on "Fox & Friends" by focusing on the values of hard work and service shared by Americans across the country. 

"I wholeheartedly disagree with what Bill is saying there. I'm blessed to be from the Heartland," said Noem, the first woman to be elected governor in the state. 

She challenged the "Real Time" host to "spend some time in South Dakota" and meet the "phenomenal people" who live there. 

"[They] love our country. They're raising their families in communities that take care of each other, that serve each other and have a work ethic that cannot be compared to anyone else. Our people in the Heartland do the hard work that makes this country strong. We're just so proud of where we are and where we come from."

Watch the full interview above. 

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