Fox News senior political analyst Brit Hume said that President Trump's Supreme Court nominee to replace retiring Justice Anthony Kennedy will result in an "ugly" battle that the nation has never seen before.

The centrist Kennedy's retirement will give Trump the opportunity to move the court solidly to the right, and a vacancy on the court could become a key issue in the midterm elections. 

"All the old rules are off the table," Hume said on "America's Newsroom."

"Every effort is likely to be made to portray whoever [the nominee] is as an extremist, as somebody automatically prepared to reverse Roe vs. Wade."

Judge Nap: The Key Issue After Justice Kennedy's Retirement Will Be Abortion

Trump told Fox Business Network's Maria Bartiromo that he expects his pick “to go very quickly,” and that he likely will not ask the for the nominee's stance on Roe v. Wade.

"That's a big one. Probably not," Trump said, adding that he has been advised not to do that but is looking to pick a "conservative" similar to Justice Neil Gorsuch.

Trump also said he'll name a candidate on July 9.

Sen. Susan Collins (R-Maine) said Sunday in an ABC interview that she has ruled out multiple candidates on the list released by the White House last fall.

"A candidate for this important position who would overturn Roe v. Wade would not be acceptable to me because that would indicate an activist agenda that I don't want to see a judge have," Collins said.

Hume called Collins' comments "completely reasonable" and that even if asked, a nominee would never answer a question about Roe vs. Wade.

"You just don't answer questions about issues that could come before you," Hume said.

Watch more from America's Newsroom above.

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