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Ellen DeGeneres denounced Mississippi's new religious freedom law, calling it the "definition of discrimination" against the LGBT community. 

Opening her talk show on Wednesday, DeGeneres said she normally stays away from political commentary, but sees this as a "human rights" issue.

The controversial law, signed Tuesday by Republican Gov. Phil Bryant, allows religious groups and some private businesses to refuse service to lesbian, gay, bisexual and transgender people based on religious beliefs.

Such measures have emerged in various states in response to a Supreme Court decision last summer that effectively legalized gay marriage nationwide.

DeGeneres inserted many many bits of humor into the serious monologue:

I’m disappointed for several reasons. First of all, Mississippi is the only state I know how to spell. Second of all, that is the definition of discrimination. It is also something that the Supreme Court already ruled on when they made marriage a right for everyone. Everyone. And they’re Supreme. I mean, that’s the best you can get. It’s like the Nacho Supreme from Taco Bell.

She then called on gay and transgender people in these states not to "lose hope" because people are "judging you over who you love."

"I was fired for being gay, and I know what it feels like. I lost everything. But look at me now. I could buy that governor's mansion, flip it and make a $7 million profit."

Watch Ellen's full comments above.

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