Vice President and possible 2016 presidential candidate Joe Biden ripped Donald Trump's campaign message as "sick" and predicted that it will not work in an election. 

"There's one guy absolutely denigrating an entire group of people, appealing to the baser side of human nature, working on this notion of xenophobia in a way that hasn't occurred in a long time," Biden said at a Hispanic Heritage Month event.

He went on to say that Americans are on the Democrats' side on the issue of immigration.

"This will pass. Trump and the stuff you're hearing on the other team. This isn't about Democrat or Republican. It's about a sick message. This message has been tried on America many times before. We've always, always, always, always, always overcome it," he said. 

Meantime, a new ad from the National Immigration Action Fund draws on the words of Ronald Reagan in 1989, contrasting the famed "shining city" message with Trump's remarks about Mexican drug dealers and rapists illegally entering the country. 

The ad will reportedly run mainly on CNN, which is hosting tonight's second GOP debate at the Ronald Reagan Presidential Library in California.

The "Outnumbered" panel reacted to the comments (video above) from Biden this afternoon, with Andrea Tantaros viewing it as another "Beltway dinosaur" going after Trump. 

She asked Republican strategist Tony Sayegh whether Biden is "worried" about Trump's growing popularity. 

Sayegh said he believes the comments show that Democrats are worried that Hillary Clinton and Bernie Sanders "aren't dealing with Trump the right way." 

"It's a recognition from Democrats that Hillary Clinton is not doing the job," he said, pointing out that Trump is now ahead of Clinton in some polls.

He said Clinton's poll numbers on trustworthiness and likability are "underwater" and Democrats are realizing they need someone else to step in.