Sen. Marco Rubio (R-Fla.) stopped by "Fox and Friends" to discuss his newly-announced presidential bid and a low blow from Senate Minority Leader Harry Reid (D-Nev.)

Reid was asked on CNBC who he thinks will be the 2016 presidential nominee on the Republican side.

"I don't really care. I think they're all losers," said Reid.

Brian Kilmeade asked Rubio whether his feelings were hurt. 

“No, not really," he responded. "The worst thing we can do is talk about it. That’s what he wants.”

He went on to note that "there used to be a line of civility in American politics" and called out the left for refusing to have a civil debate about ideas put forth from the other side. 

"Their almost-instant reaction is to attack you personally and call you a name. I'm not saying people on the right don't do it too, because it happens, but it's so much more common on the left," said Rubio.

The "Outnumbered" panel reacted this afternoon to Reid's latest inflammatory statement, highlighting some other comments over the years that have crossed the line. 

Andrea Tantaros said she doesn't take Reid seriously, questioning whether he has any credibility anymore. 

She argued that Democrats are going to have to do better than attacks like this one if they want to win in 2016.

Fox News chief Washington correspondent James Rosen noted that when it comes to crossing the line with political rhetoric, there is no comparison to Reid. 

"There is no one quite like Harry Reid," he said, while Kirsten Powers pointed out that she believes Democrats are "relieved" that Reid will retire at the end of his term. 

Powers said the party needs to replace Reid as Senate leader with someone like Chuck Schumer (D-N.Y.), who can "actually talk to members of the other party."

Watch the Rubio interview above and the "Outnumbered" discussion below.