Programming Note: Don't miss Greta Van Susteren's interview with Israeli Prime Minister Benjamin Netanyahu, Thursday at 7p/2a ET on "On the Record."

In a speech at the UN earlier this week, Israeli Prime Minister Benjamin Netanyahu issued a dire warning for the world of the danger of a nuclear Iran.

"Once Iran produces atomic bombs, all the charms and all the smiles will suddenly disappear. They’ll just vanish. And it's then that the ayatollahs will show their true face and unleash their aggressive fanaticism on the entire world," Netanyahu said.

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Last week on “The Factor,” Charles Krauthammer said that President Obama and his administration are “surrendering” to Iran on the nuclear weapons front.

Tonight, Krauthammer returned to the show and warned that this is the biggest story of the year, and no one is listening.

“History will remember this year for nothing else than the surrender on Iran,” Krauthammer said. “That will be the major event of 2014.”

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He added that President Obama gave up on these negotiations with Iran long ago, judging by his actions – first, he weakened the sanctions against Iran before even sitting at the negotiation table, and second, he conceded in advance the principle of enriching uranium.”

“Even if the negotiations are successful, it will leave Iran a few months away from a bomb," Krauthammer said. "We know it, Obama knows, Iran knows it, the world knows it.”

O’Reilly pointed out that Israel is not just going to sit back and let Iran acquire these weapons, and their response would likely include going to war.

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“This is a man who knows the weight of history is on his shoulders,” Krauthammer said of Netanyahu. “And he’s aware that Jewish history relies on his making the right decision.”

“The only thing that will restrain [Israel] is if they think they do not have the capacity.”

Watch the clip above and be sure to check out Krauthammer's best-selling book Things That Matter.

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