UPDATE: 2:57p ET: A single-engine private plane carrying three people from Rochester, NY, has crashed in Jamaica after overshooting its Naples, Fla., destination, and mysteriously failing to respond to repeated calls. 

UPDATE, 2:10p ET: The plane has left Cuban airspace and is now heading toward Jamaica.

It is reportedly owned by a developer from Rochester who maintains properties in Naples.

Two F-15s fighter jets are tracking an unresponsive private aircraft that took off from Rochester, NY, heading for Naples, Fla. The plan has not answered repeated calls, and has entered Cuban air space.

Read more below from FoxNews.com:

The Socata TBM-700, a light business and utility plane, took off from Rochester, N.Y., and was headed to Naples, Fla. The plane's occupants have not responded to any communication attempts. NORAD said the cause could be hypoxia. A fighter jet pilot observed condensation on one of the small plane's windows. 

The plane reached the altitude of 25,000 feet, MyFoxTampaBay.com reported.