Harold Ramis, best known as an actor in the films 'Ghostbusters' and 'Stripes,' as well as a director of movies such as 'Caddyshack,' has died at 69 from health struggles, his spokesman says.

FoxNews.com reports:

Ramis suffered from autoimmune inflammatory vasculitis, a disease that causes swelling in the blood vessels, and died from complications of the illness, surrounded by his family.

A graduate of the famed Second City comedy theater, Ramis got his start in show business writing films like “National Lampoon’s Vacation” and “Ghostbusters,” which he also acted in.

He most recently directed episodes of “The Office.” He first got sick in 2010, his wife told The Tribune.

Ramis is survived by his wife, Erica Mann Ramis, and children Violet Stiel, Julian and Daniel Ramis. He also has two grandchildren.