Charles Krauthammer said the possible departure of Attorney General Jeff Sessions could have serious consequences for the Trump administration.
White House Press Secretary Sean Spicer said he hadn't spoken with Trump about his confidence in Sessions in light of an ABC report.
The report said Sessions' relationship with the president has disintegrated so much that the former Alabama senator suggested he might resign.
Krauthammer pointed out that the last time Spicer said he "hadn't spoken with Trump" about a member of the administration, then-FBI Director James Comey was fired days later.
"This is really bad," Krauthammer said.
Trump is reportedly extremely frustrated that Sessions recused himself from the Russia investigation.
Krauthammer said that if the president does not have enough "self-control" to prevent the departure of a "pillar of the administration," it could spell doom for the presidency.
"If you can't absorb this one issue on which he disagrees and you have to get rid of him, no one is safe," Krauthammer said, adding that it would turn the Trump White House into an "intrinsically unstable administration."
Watch the clip above.