Sen. Ted Cruz was on “The Kelly File” tonight to call for Secretary of State John Kerry’s resignation over his apartheid remarks concerning Israel.

Cruz called the comments “extraordinarily troubling” and noted that they were delivered on the eve of Holocaust Remembrance Day, calling it “unacceptable.”

“Apartheid is a word weighted with history,” he said, stressing that Kerry’s statements will be reiterated by anti-Semites.

“Words have meaning,” he told Megyn Kelly.

In a statement issued tonight, Kerry said:

First, Israel is a vibrant democracy and I do not believe, nor have I ever stated, publicly or privately, that Israel is an apartheid state or that it intends to become one.  Anyone who knows anything about me knows that without a shred of doubt.

Second, I have been around long enough to also know the power of words to create a misimpression, even when unintentional, and if I could rewind the tape, I would have chosen a different word to describe my firm belief that the only way in the long term to have a Jewish state and two nations and two peoples living side by side in peace and security is through a two state solution.

Watch Cruz’s full interview above.

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